SECRET domain of variola virus CrmB protein can be a member of poxviral type II chemokine-binding proteins family
Abstract Background Variola virus (VARV) the causative agent of smallpox, eradicated in 1980, have wide spectrum of immunomodulatory proteins to evade host immunity.Recently additional biological activity was discovered for VARV CrmB protein, known to Hay bags bind and inhibit tumour necrosis factor (TNF) through its N-terminal domain homologous to